Endocrine Abstracts

It is now 15 years since the discovery of Sry as the primary “testis-determining gene” and Koopman et al.’s classic experiment showing that transgenic expression of Sry in XX mice results in testis development and a male phenotype. Although studies in mice are continuing to provide exciting information about the biology of sex development, significant progress is also being made in our understanding of the molecular mechanisms of gonad devel...